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- How Naloxone Helps Reverse Opiate Overdose Effects - Opiate overdose, whether caused by prescription drugs or illicit opiates, can be fatal. Fortunately, naloxone, an opiate antagonist, can reverse the overdose effects, often saving a person’s life. What Happens During Opiate Overdose? Overdose is a very common outcome of opiate addiction. It is also common for many recovering addicts to relapse and take the same ...